CADASIL

A familial, cerebral arteriopathy mapped to chromosome 19q12, and characterized by the presence of granular deposits in small CEREBRAL ARTERIES producing ischemic STROKE; PSEUDOBULBAR PALSY; and multiple subcortical infarcts (CEREBRAL INFARCTION). CADASIL is an acronym for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. CADASIL differs from BINSWANGER DISEASE by the presence of MIGRAINE WITH AURA and usually by the lack of history of arterial HYPERTENSION. (From Bradley et al, Neurology in Clinical Practice, 2000, p1146)

Also Known As:

CADASILM; Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy; Dementia, Hereditary Multi-Infarct Type; Dementia, Hereditary Multi Infarct Type

Nervous System Diseases: 14737
- Central Nervous System Diseases: 4371
  - Brain Diseases: 16141
    - Dementia: 39493
      - Vascular Dementia: 2489
        CADASIL: 490
    - Cerebrovascular Disorders: 7764
      - Stroke: 105876
        Brain Infarction: 1730
        Cerebral Infarction: 7793
        CADASIL: 490
      - Brain Ischemia: 19602
        Brain Infarction: 1730
        Cerebral Infarction: 7793
        CADASIL: 490
      - Vascular Dementia: 2489
        CADASIL: 490
      - Cerebral Small Vessel Diseases: 676
        CADASIL: 490
      - Intracranial Arterial Diseases: 8
        Cerebral Arterial Diseases: 27
        CADASIL: 490
Cardiovascular Diseases: 94258
- Vascular Diseases: 15340
  - Cerebrovascular Disorders: 7764
    - Stroke: 105876
      - Brain Infarction: 1730
        Cerebral Infarction: 7793
        CADASIL: 490
    - Brain Ischemia: 19602
      - Brain Infarction: 1730
        Cerebral Infarction: 7793
        CADASIL: 490
    - Cerebral Small Vessel Diseases: 676
      - CADASIL: 490
    - Intracranial Arterial Diseases: 8
      - Cerebral Arterial Diseases: 27
        CADASIL: 490
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Inborn Genetic Diseases: 12342
  - CADASIL: 490
Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10385
  - Necrosis: 83944
    - Infarction: 38053
      - Brain Infarction: 1730
        Cerebral Infarction: 7793
        CADASIL: 490
  - Ischemia: 77203
    - Infarction: 38053
      - Brain Infarction: 1730
        Cerebral Infarction: 7793
        CADASIL: 490

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